Monash BDI researchers make Highly Cited list for the fourth consecutive year

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Two Monash Biomedicine Discovery Institute (BDI) researchers have been recognised for their exceptional research performance, determined by production of multiple highly cited papers that rank in the top one per cent by citations for a field and year.

Professor Jamie Rossjohn and Professor Charles Mackay have each been ranked as a 2021 Highly Cited Researcher in the prestigious list released in November by Clarivate Analytics.

Professor Rossjohn’s research focus is on understanding, at the molecular level, how the T cell receptor specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of protective immunity, autoimmunity and other adverse T cell reactivities. Further, he has pioneered the molecular understanding of lipid and metabolite based immunity by T cells that recognise HLA class-I like molecules, CD1 and MR1, respectively. This is the fourth consecutive year that Professor Rossjohn has appeared on the Clarivate Analytics Highly Cited Researcher list.

Professor Mackay has forged a new understanding of the gut microbiome and the important role it plays in immune responses including allergies and in a number of diseases including type 1 diabetes. His research into how immune responses can be manipulated using ‘medicinal foods’, as well as novel gut microbial species, is attracting both clinical and public interest, with the latest research findings moving to clinical trials.

Professor Mackay was highly cited from 2005 to 2010 under what was then the Institute for Scientific Information citation, and has remained on the Clarivate Analytics Highly Cited Researcher list since 2017.

The Highly Cited Researcher list, now in its eighth year, determines the ‘who’s who’ of influential researchers, drawing on data and analysis to identify the world’s leading researchers who have demonstrated significant and broad influence. See the full list of researchers on the Web of Science:  Nineteen researchers from Monash University were recognised this year.

Image: Professor Jamie Rossjohn and Professor Charles Mackay

Original article

The interplay between diet, the microbiota and immunity

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Research in mice shows how diet alters immune system function through a gut microbe

At a glance:

  • Research in mice demonstrates how diet alters a gut microbe molecule that in turn prompts immune cells to downregulate inflammation
  • Study illustrates the molecular mechanism behind the longstanding view that diet, microbiota and immunity influence each other in myriad ways
  • Following more testing, findings could inform the design of small-molecule drugs that regulate immune response to treat inflammatory conditions

An international team of researchers including Monash University have found molecular proof of how diet ultimately affects immunity through the gut microbiome.

The team’s work, conducted in mice, have pinpointed a microbial molecule called B. fragilis that sets off an immune-signalling cascade triggered by the host’s diet of a metabolic breakdown of branch-chained amino acids in the mouse gut.

The multistep pathway begins with B. fragilis taking up the branch-chained amino acids and then converting them by a specific enzyme into sugar-lipid molecules that also have branched chains that are then spotted and picked up by a class of immune-signalling cells known as antigen-presenting cells, which in turn induce natural killer T (NKT) cells to exercise their immunoregulatory response through upregulating inflammation-controlling genes and immune-regulatory chemicals.

Furthermore, the team found that B. fragilis alters the structure of the sugar-lipid molecules that it metabolizes and renders them better capable of binding to receptors on specific immune cells and initiating a signalling cascade that culminates in downregulating inflammation.

The findings, published November 10 in Nature, offer a unifying explanation for the complex interplay between diet, gut microbiota and immune function. They are the result of collaboration among scientists at Harvard Medical School, Brigham and Women’s Hospital, Seoul National University, and Monash University in Australia.

NKT cells line the human gastrointestinal tract, the lungs and are also found in the liver and spleen and likely play a significant role in immune regulation and are implicated in a range of inflammatory conditions including ulcerative colitis, and to a possible role in airway inflammatory conditions, such as asthma.

While scientists have surmised for a long time that diet plays a role in immune health, the new study elucidates the precise molecular cascade behind diet and immune health, said study senior author Dennis Kasper, professor of immunology at Harvard Medical School.

“We have shown how diet affects the immune system through a microbe mediator in the gut, and this is a really striking example of the diet-microbiota-immunity triad at play,” Kasper said. “What this work really does is provide a step-by-step pathway from beginning to end that explains how and why this triad works and how diet ultimately affects the immune system.”

Using a structural biology approach, Professor Jamie Rossjohn, ARC Laureate Fellow at the Monash Biomedicine Discovery Institute, elucidated how the lipid structure engages with and binds to antigen-presenting cells—the immune cells that give NKT cells the go-ahead to produce anti-inflammatory chemicals.

“This work offers a great example of trans-disciplinary discovery-based research aimed at answering a major question in biomedical sciences, namely how the immune system can be modulated by the interplay between diet and the microbiota,” Professor Rossjohn said.

Study coinvestigator Seung Bum Park, professor of chemistry at Seoul National University, synthesized and the Harvard team tested 23 different configurations of the microbe-made immunomodulatory molecule to determine how each one interacts with the immune cells that regulate inflammation.

“Our new work demonstrates that the branching of the lipid structure induces a very different response—the branching in the structure induces an anti-inflammatory rather than a proinflammatory response,” Professor Kasper said.

The findings offer the hope that inflammatory diseases mediated by these NKT cells could one day be treated with inflammation-dampening microbial molecules made in the lab, the researchers said.

Co-authors included Sungwhan F. Oh, T. Praveena, Heebum Song, Ji-Sun Yoo, Da-Jung Jung, Deniz Erturk-Hasdemir1, Yoon Soo Hwang, ChangWon Lee, Jérôme Le Nours, Hyunsoo Kim, Jesang Lee, and Richard Blumberg.

Read the full paper (view only)  via SharedIt in Nature titled: Host immunomodulatory lipids created by symbionts from dietary amino acids. 

Original article

Congrats Jamie: Highly Cited researcher again!

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Congratulations to Jamie who is again on the Highly Cited Researchers 2021 list of the world’s most Highly Cited Scientists, which is published annually by Clarivate Analytics.

From Clarivate: Recognising the true pioneers in their fields over the last decade, demonstrated by the production of multiple highly-cited papers that rank in the top 1% by citations for field and year in the Web of Science™. Of the world’s scientists and social scientists, Highly Cited Researchers truly are one in 1,000.

Original article