1. The role of the γδ T cell receptor (TCR) in microbial infection.
2. Maintenance of tissue homeostasis by unconventional T cells.
3. Anti-microbial immune responses of unconventional T cells.
Human gd T cell lineages. We have provided significant insight into the immunobiology of human gd T cells. Each gd T cell population can be divided based on their Vd chain usage. Each subset is displayed alongside a set of cell surface markers that define them in the steady state. Vg9–/Vd2+ and Vd1+ gd T cells undergo postnatal clonal selection in the periphery from a naïve gd T cell pool. Vg9+/Vd2+ T cells are established in the perinatal period and are rapidly matured after birth, resulting in a uniform responsiveness to a bacterial metabolite (HMB-PP). Non-Vd1 or Vd2 T cells, express a Vd3-8 TCR chain pairing and a rare fraction in the peripheral blood but are enriched in the tissues, such as the liver. We use this unique knowledge to perform cutting edge experiments, in samples from patients who have been infected by some of the world’s most challenging diseases, to inform future vaccination strategies to better protect us.