Professor Jamie Rossjohn
Professor Jamie Rossjohn FAA FAHMS FLSW FMedSci FRS
Prof. Jamie Rossjohn’s research is centred on an understanding immunity. He is currently a NHMRC Investigator L3 Fellow (2022-26) and previously an ARC Australian Laureate Fellow (2017-21), NHMRC Australia Fellow (2011-16) and ARC Federation Fellow (2007-11). He was the former Head of the Infection and Immunity Program (2016-19) of the Biomedicine Discovery Institute. In 2022, Prof. Rossjohn was elected as a Fellow of the Royal Society and Associate Member of EMBO.
Prof. Rossjohn is known for his contributions to the understanding the molecular basis underpinning immunity. He has used structural biology to explain pre-T- cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T- cell reactivity.
He has unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. He has pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity.
Recently he has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen. Collectively, he has published > 465 papers and mentored numerous researchers towards obtaining higher degrees and nationally competitive fellowships.
What We Do
The laboratory is currently investigating two broad, yet interrelated areas addressing pivotal molecular interactions in immunity: Our program is inter-linked to create a complete systematic study, namely host recognition, responses developed by the pathogen, and drug design to modulate and/or counteract these events.
Here we aim to provide a fundamental advancement of knowledge of events that are central to innate and adaptive immunity. Understanding the structural and biophysical basis of MHC-restriction, TCR engagement, the structural correlates of T-cell signalling is significant; they represent central questions in the field of adaptive immunity. Moreover, investigating the structural basis of T-cell allorecognition, and T-cell mediated autoimmunity, will collectively provide clear insights into immune dysfunction. In addition, focusing on generic components of innate immunity is important, as the mechanisms underlying innate recognition, is simply unknown.
Recent Fellowship and Award Success
- Prof. Jamie Rossjohn elected Fellow of the Royal Society
- Prof. Jamie Rossjohn elected Associate Member of EMBO
- Prof. Jamie Rossjohn NHMRC Investigator Leadership 3 Fellowship
- Dr Ben Gully, Future Leader Postdoctoral Fellowship 2023
- Dr Praveena Thirunavukkarasu, ARC DECRA Fellow
- Dr Wael Awad ARC DECRA Fellow
- Dr Adam Shahine ARC DECRA Fellow
- Dr Martin Davey ARC DECRA Fellow
- Dr Laura Ciacchi, Monash Thesis BDI Highly commended Award for 2022
- Dr Wael Awad 2022 Eppendorf Edman ECR Award
- Dr Adam Shahine The Dean’s Awards for Excellence in Research – Early Career Researcher
- Dr Anouk von Borstel ASI Postdoc Career Advancement Award
- Dr Karin Schmidt Marie Skłodowska-Curie Fellow
- Dr Jerome Le Nours ARC Future fellow (2016-20)
- Prof. Jamie Rossjohn ARC Australian Laureate Fellow (2016-21)
- Monash and Janssen Multi Year Research Collaboration (Watch video: Collaborating for What’s Now & What’s Next)
- Monash and Immutep Multi Year Research Collaboration
- Future students
- Monash Sensory Science
- Disability student scholarships and graduate internships
Celebrating International Women’s Day/in News /by Jennifer Huynh
March 8th marks International Women’s Day, a global celebration of the social, economic, cultural, and political achievements of women. This year’s theme is “Choose to Challenge,” which encourages everyone to challenge gender bias and inequality and create a more inclusive world. In the field of Science, women have made significant contributions, from Marie Curie’s groundbreaking […]
Congrats to our newly appointed BDI Group Leaders: Wael, Jan and Adam/in News /by Jennifer Huynh
Monash BDI announce new Group Leaders Monash Biomedicine Discovery Institute (BDI) is excited to announce 13 newly selected Group Leaders. These Group Leaders are part of a program created by Monash BDI to help early career researchers (ECRs) bridge the gap between senior postdoctoral fellow and independent lab head. Professor Dena Lyras, Deputy Director at […]
Congrats Ben on the award of the Future Leader Postdoctoral Fellowship/in News /by Jennifer Huynh
Monash BDI success in Faculty fellowships Six postdoctoral researchers from the Monash Biomedicine Discovery Institute (BDI) have received fellowships in two separate schemes offered by the Faculty of Medicine, Nursing and Health Sciences (MNHS). These awards will support outstanding early career researchers at key points in their careers. This opportunity allows them to continue to […]
Congrats Ben on your successful ARC discovery grant/in News /by Jennifer Huynh
Monash BDI awarded more than $7m in ARC funding In the latest round of Australian Research Council (ARC) funding, Monash Biomedicine Discovery Institute (BDI) researchers have been awarded 14 Discovery Project grants, worth more than $7 million. The funded projects are expected to advance knowledge in a range of areas, from understanding why it is […]