Rossjohn Laboratory

Understanding immune function and dysfunction.

Dr. Jan Petersen
Research Fellow
Anti-microbial immunity

The immune system walks a fine line – it must be sensitive enough to recognise foreign pathogens like viruses and bacteria, but avoid attacking uninfected and healthy cells. We investigate how T cells recognise microbial peptide antigens presented by major histocompatibility complex (MHC) molecules, and aim to decipher the molecular mechanisms that ultimately define the ability of the adaptive immune system to distinguish between self and foreign. Therefore, understanding of the molecular basis of T cell recognition in the context of infection has far-reaching implications in the areas of transplantation, autoimmunity and cancer.