Rossjohn Laboratory

Understanding immune function and dysfunction.

Publication Highlights

Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling

Science 04 Jun 2021:
Vol. 372, Issue 6546, eabe9124
DOI: 10.1126/science.abe9124

Abstract.

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Artwork: Erica Tandori

Holding-the-Keys-to-Rheumatoid-Arthritis

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR

Science Immunology 16 Apr 2021:
Vol. 6, Issue 58, eabe0896
DOI: 10.1126/sciimmunol.abe0896

Summary. Abstract. TOC. Full text.

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Artwork: Erica Tandori

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

Nat Commun 12,2173 (2021).

https://doi.org/10.1038/s41467-021-22359-x

Abstract. Full text.

Obituary: Katharina Gaus 1972–2021

Nat Immunol (2021).

https://doi.org/10.1038/s41590-021-00915-30

Full text.

Image courtesy of ARC Centre of Excellence in Advanced Molecular Imaging

The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage

Science 2021, 371(6536),1383-1388
DOI: 10.1126/science.abe7070

Abstract. Full text. Reprint.

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Artwork: Erica Tandori

A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

Nature Cancer (2020). DOI: 10.1038/s43018-020-00111-6

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Artwork: Erica Tandori

Molecular-mimicry-in-Celiac-Disease,-by-Erica-Tandori-SMALL_edit

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.

Nat Struct Mol Biol. 2020 Jan;27(1):49-61

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Artwork: Erica Tandori

The molecular basis underpinning the potency and specificity of MAIT cell antigens

Nat Immunol. 2020;10.1038/s41590-020-0616-6.

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Artwork: Erica Tandori

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

Sci Immunol. 2020;5(49):eabc9492.

Summary. Abstract. Full text.

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Artwork: Erica Tandori

The Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

iScience. 2020, 23(7):101258

Open access article

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Artwork: Erica Tandori

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

Sci Immunol. 2020 Jan 3;5(43). pii: eaax5430.

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Artwork: Erica Tandori

jerome-paper-LETTERS-MERGED-WITH-CIRCLE-LATSEST-VERSION-TRANSPARENT-CIRCLE_400px

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Science. 2019;366(6472):1522-1527.

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Artwork: Erica Tandori

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

^{Nature. 2017 May 11;545(7653):243-247.}

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Artwork: Vanette Tran

CD4⁺ T cell-mediated HLA class II cross-restriction in HIV controllers.

Sci Immunol. 2018 Jun 8;3(24).

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Artwork: Vanette Tran

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

^{Cell. 2017;169(1):58-71.e14.}

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Artwork: Vanette Tran

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

^{Nat Immunol. 2017 Apr;18(4):402-411.}

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Artwork: Vanette Tran

Recent Publications

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.

Lim JJ, Jones CM, Loh TJ, Ting YT, Zareie P, Loh KL, Felix NJ, Suri A, McKinnon M, Stevenaert F, Sharma RK, Klareskog L, Malmström V, Baker DG, Purcell AW, Reid HH, La Gruta NL, Rossjohn J.

Sci Immunol. 2021 Apr 16;6(58):eabe0896. doi: 10.1126/sciimmunol.abe0896.
Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1.

Howson LJ, Awad W, von Borstel A, Lim HJ, McWilliam HEG, Sandoval-Romero ML, Majumdar S, Hamzeh AR, Andrews TD, McDermott DH, Murphy PM, Le Nours J, Mak JYW, Liu L, Fairlie DP, McCluskey J, Villadangos JA, Cook MC, Turner SJ, Davey MS, Ojaimi S, Rossjohn J.

Sci Immunol. 2020 Jul 24;5(49):eabc9492. doi: 10.1126/sciimmunol.abc9492.
Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.

Littler DR, Gully BS, Colson RN, Rossjohn J.

iScience. 2020 Jul 24;23(7):101258. doi: 10.1016/j.isci.2020.101258. Epub 2020 Jun 9.
Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

Nicolai S, Wegrecki M, Cheng TY, Bourgeois EA, Cotton RN, Mayfield JA, Monnot GC, Le Nours J, Van Rhijn I, Rossjohn J, Moody DB, de Jong A.

Sci Immunol. 2020 Jan 3;5(43). pii: eaax5430. doi: 10.1126/sciimmunol.aax5430. Epub 2020 Jan 3.
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.

Petersen J, Ciacchi L, Tran MT, Loh KL, Kooy-Winkelaar Y, Croft NP, Hardy MY, Chen Z, McCluskey J, Anderson RP, Purcell AW, Tye-Din JA, Koning F, Reid HH, Rossjohn J.

Nat Struct Mol Biol. 2019 Dec 23. doi: 10.1038/s41594-019-0353-4. [Epub ahead of print]
A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Le Nours J, Gherardin NA, Ramarathinam SH, Awad W, Wiede F, Gully BS, Khandokar Y, Praveena T, Wubben JM, Sandow JJ, Webb AI, von Borstel A, Rice MT, Redmond SJ, Seneviratna R, Sandoval-Romero ML, Li S, Souter MNT, Eckle SBG, Corbett AJ, Reid HH, Liu L, Fairlie DP, Giles EM, Westall GP, Tothill RW, Davey MS, Berry R, Tiganis T, McCluskey J, Pellicci DG, Purcell AW, Uldrich AP, Godfrey DI, Rossjohn J.

Science. 2019 Dec 20;366(6472):1522-1527. doi: 10.1126/science.aav3900.
Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors.

Almeida CF, Sundararaj S, Le Nours J, Praveena T, Cao B, Burugupalli S, Smith DGM, Patel O, Brigl M, Pellicci DG, Williams SJ, Uldrich AP, Godfrey DI, Rossjohn J.

Nat Commun. 2019 Nov 20;10(1):5242. doi: 10.1038/s41467-019-12941-9.
Click for full listing of publications

Rossjohn Laboratory

Publication Highlights

Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

Obituary: Katharina Gaus 1972–2021

The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage

A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.

The molecular basis underpinning the potency and specificity of MAIT cell antigens

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

The Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

CD4⁺ T cell-mediated HLA class II cross-restriction in HIV controllers.

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Recent Publications

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