Rossjohn Laboratory

Understanding immune function and dysfunction.

Publication Highlights

A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

Nature Cancer (2020). DOI: 10.1038/s43018-020-00111-6

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Artwork: Erica Tandori

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

Sci Immunol. 2020;5(49):eabc9492.

Summary. Abstract. Full text.

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Artwork: Erica Tandori

The Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

iScience. 2020, 23(7):101258

Open access article

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Artwork: Erica Tandori

The molecular basis underpinning the potency and specificity of MAIT cell antigens

Nat Immunol. 2020;10.1038/s41590-020-0616-6.

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Artwork: Erica Tandori

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T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.

Nat Struct Mol Biol. 2020 Jan;27(1):49-61

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Artwork: Erica Tandori

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A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Science. 2019;366(6472):1522-1527.

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Artwork: Erica Tandori

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

Sci Immunol. 2020 Jan 3;5(43). pii: eaax5430.

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Artwork: Erica Tandori

CD4⁺ T cell-mediated HLA class II cross-restriction in HIV controllers.

Sci Immunol. 2018 Jun 8;3(24).

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Artwork: Vanette Tran

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

^{Nature. 2017 May 11;545(7653):243-247.}

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Artwork: Vanette Tran

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

^{Cell. 2017;169(1):58-71.e14.}

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Artwork: Vanette Tran

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

^{Nat Immunol. 2017 Apr;18(4):402-411.}

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Artwork: Vanette Tran

Recent Publications

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1.

Howson LJ, Awad W, von Borstel A, Lim HJ, McWilliam HEG, Sandoval-Romero ML, Majumdar S, Hamzeh AR, Andrews TD, McDermott DH, Murphy PM, Le Nours J, Mak JYW, Liu L, Fairlie DP, McCluskey J, Villadangos JA, Cook MC, Turner SJ, Davey MS, Ojaimi S, Rossjohn J.

Sci Immunol. 2020 Jul 24;5(49):eabc9492. doi: 10.1126/sciimmunol.abc9492.
Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.

Littler DR, Gully BS, Colson RN, Rossjohn J.

iScience. 2020 Jul 24;23(7):101258. doi: 10.1016/j.isci.2020.101258. Epub 2020 Jun 9.
Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

Nicolai S, Wegrecki M, Cheng TY, Bourgeois EA, Cotton RN, Mayfield JA, Monnot GC, Le Nours J, Van Rhijn I, Rossjohn J, Moody DB, de Jong A.

Sci Immunol. 2020 Jan 3;5(43). pii: eaax5430. doi: 10.1126/sciimmunol.aax5430. Epub 2020 Jan 3.
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.

Petersen J, Ciacchi L, Tran MT, Loh KL, Kooy-Winkelaar Y, Croft NP, Hardy MY, Chen Z, McCluskey J, Anderson RP, Purcell AW, Tye-Din JA, Koning F, Reid HH, Rossjohn J.

Nat Struct Mol Biol. 2019 Dec 23. doi: 10.1038/s41594-019-0353-4. [Epub ahead of print]
A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Le Nours J, Gherardin NA, Ramarathinam SH, Awad W, Wiede F, Gully BS, Khandokar Y, Praveena T, Wubben JM, Sandow JJ, Webb AI, von Borstel A, Rice MT, Redmond SJ, Seneviratna R, Sandoval-Romero ML, Li S, Souter MNT, Eckle SBG, Corbett AJ, Reid HH, Liu L, Fairlie DP, Giles EM, Westall GP, Tothill RW, Davey MS, Berry R, Tiganis T, McCluskey J, Pellicci DG, Purcell AW, Uldrich AP, Godfrey DI, Rossjohn J.

Science. 2019 Dec 20;366(6472):1522-1527. doi: 10.1126/science.aav3900.
Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors.

Almeida CF, Sundararaj S, Le Nours J, Praveena T, Cao B, Burugupalli S, Smith DGM, Patel O, Brigl M, Pellicci DG, Williams SJ, Uldrich AP, Godfrey DI, Rossjohn J.

Nat Commun. 2019 Nov 20;10(1):5242. doi: 10.1038/s41467-019-12941-9.
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Rossjohn Laboratory

Publication Highlights

A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

The Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

The molecular basis underpinning the potency and specificity of MAIT cell antigens

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

CD4⁺ T cell-mediated HLA class II cross-restriction in HIV controllers.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Recent Publications

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