Rossjohn Laboratory

Understanding immune function and dysfunction.

Publications Highlights

The molecular basis underpinning the potency and specificity of MAIT cell antigens

Nat Immunol. 2020;10.1038/s41590-020-0616-6.

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T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.

Nat Struct Mol Biol. 2019 Dec 23. doi: 10.1038/s41594-019-0353-4.

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

Sci Immunol. 2020 Jan 3;5(43). pii: eaax5430. doi: 10.1126/sciimmunol.aax5430.

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A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Science. 2019 Dec 20;366(6472):1522-1527. doi: 10.1126/science.aav3900.

CD4⁺ T cell-mediated HLA class II cross-restriction in HIV controllers.

Sci Immunol. 2018 Jun 8;3(24). pii: eaat0687. doi: 10.1126/sciimmunol.aat0687.

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

^{Nat Immunol. 2017 Apr;18(4):402-411. doi: 10.1038/ni.3679. Epub 2017 Feb 6.}

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

^{Cell. 2017 Mar 23;169(1):58-71.e14. doi: 10.1016/j.cell.2017.03.002.}

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

^{Nature. 2017 May 11;545(7653):243-247. doi: 10.1038/nature22329. Epub 2017 May 3.}

Recent Publications

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

Nicolai S, Wegrecki M, Cheng TY, Bourgeois EA, Cotton RN, Mayfield JA, Monnot GC, Le Nours J, Van Rhijn I, Rossjohn J, Moody DB, de Jong A.

Sci Immunol. 2020 Jan 3;5(43). pii: eaax5430. doi: 10.1126/sciimmunol.aax5430. Epub 2020 Jan 3.
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.

Petersen J, Ciacchi L, Tran MT, Loh KL, Kooy-Winkelaar Y, Croft NP, Hardy MY, Chen Z, McCluskey J, Anderson RP, Purcell AW, Tye-Din JA, Koning F, Reid HH, Rossjohn J.

Nat Struct Mol Biol. 2019 Dec 23. doi: 10.1038/s41594-019-0353-4. [Epub ahead of print]
A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Le Nours J, Gherardin NA, Ramarathinam SH, Awad W, Wiede F, Gully BS, Khandokar Y, Praveena T, Wubben JM, Sandow JJ, Webb AI, von Borstel A, Rice MT, Redmond SJ, Seneviratna R, Sandoval-Romero ML, Li S, Souter MNT, Eckle SBG, Corbett AJ, Reid HH, Liu L, Fairlie DP, Giles EM, Westall GP, Tothill RW, Davey MS, Berry R, Tiganis T, McCluskey J, Pellicci DG, Purcell AW, Uldrich AP, Godfrey DI, Rossjohn J.

Science. 2019 Dec 20;366(6472):1522-1527. doi: 10.1126/science.aav3900.
Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors.

Almeida CF, Sundararaj S, Le Nours J, Praveena T, Cao B, Burugupalli S, Smith DGM, Patel O, Brigl M, Pellicci DG, Williams SJ, Uldrich AP, Godfrey DI, Rossjohn J.

Nat Commun. 2019 Nov 20;10(1):5242. doi: 10.1038/s41467-019-12941-9.
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