Rossjohn Laboratory

Understanding immune function and dysfunction.

Publications Highlights

CD4⁺ T cell-mediated HLA class II cross-restriction in HIV controllers.

Sci Immunol. 2018 Jun 8;3(24). pii: eaat0687. doi: 10.1126/sciimmunol.aat0687.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

^{Nature. 2017 May 11;545(7653):243-247. doi: 10.1038/nature22329. Epub 2017 May 3.}

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

^{Cell. 2017 Mar 23;169(1):58-71.e14. doi: 10.1016/j.cell.2017.03.002.}

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

^{Nat Immunol. 2017 Apr;18(4):402-411. doi: 10.1038/ni.3679. Epub 2017 Feb 6.}

Recent Publications

Human CD8⁺ T cell cross-reactivity across influenza A, B and C viruses.

Koutsakos M, Illing PT, Nguyen THO, Mifsud NA, Crawford JC, Rizzetto S, Eltahla AA, Clemens EB, Sant S, Chua BY, Wong CY, Allen EK, Teng D, Dash P, Boyd DF, Grzelak L, Zeng W, Hurt AC, Barr I, Rockman S, Jackson DC, Kotsimbos TC, Cheng AC, Richards M, Westall GP, Loudovaris T, Mannering SI, Elliott M, Tangye SG, Wakim LM, Rossjohn J, Vijaykrishna D, Luciani F, Thomas PG, Gras S, Purcell AW, Kedzierska K.

Nat Immunol. 2019 Feb 18. doi: 10.1038/s41590-019-0320-6. [Epub ahead of print]
The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network.

Neier SC, Ferrer A, Wilton KM, Smith SEP, Kelcher AMH, Pavelko KD, Canfield JM, Davis TR, Stiles RJ, Chen Z, McCluskey J, Burrows SR, Rossjohn J, Hebrink DM, Carmona EM, Limper AH, Kappes DJ, Wettstein PJ, Johnson AJ, Pease LR, Daniels MA, Neuhauser C, Gil D, Schrum AG.

Sci Immunol. 2019 Feb 15;4(32). pii: eaal2201. doi: 10.1126/sciimmunol.aal2201.
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.

Mayassi T, Ladell K, Gudjonson H, McLaren JE, Shaw DG, Tran MT, Rokicka JJ, Lawrence I, Grenier JC, van Unen V, Ciszewski C, Dimaano M, Sayegh HE, Kumar V, Wijmenga C, Green PHR, Gokhale R, Jericho H, Semrad CE, Guandalini S, Dinner AR, Kupfer SS, Reid HH, Barreiro LB, Rossjohn J, Price DA, Jabri B.

Cell. 2019 Feb 21;176(5):967-981.e19. doi: 10.1016/j.cell.2018.12.039. Epub 2019 Feb 7.
A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.

Shahine A, Reinink P, Reijneveld JF, Gras S, Holzheimer M, Cheng TY, Minnaard AJ, Altman JD, Lenz S, Prandi J, Kubler-Kielb J, Moody DB, Rossjohn J, Van Rhijn I.

Nat Commun. 2019 Jan 4;10(1):56. doi: 10.1038/s41467-018-07898-0.
Click for full listing of publications

Rossjohn Laboratory

Publications Highlights

CD4⁺ T cell-mediated HLA class II cross-restriction in HIV controllers.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Recent Publications

Click for full listing of publications

Latest News

Area

Rossjohn Laboratory

Publications Highlights

CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Recent Publications

Click for full listing of publications

Latest News

Area

CD4⁺ T cell-mediated HLA class II cross-restriction in HIV controllers.