Rossjohn Laboratory

Understanding immune function and dysfunction.

Publication Highlights

Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein

J Biol Chem. 2021 Aug 9:101065

Open access article

Image: Priyanka Chaurasia

Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 non-structural protein 9

J Biol Chem. 2021 Jul 28:101018.

Open Access article

Image: Dene Littler

CD1a selectively captures endogenous cellular lipids that broadly block T cell response

May 7, 2021
J Exp Med (2021) 218 (7): e20202699

Abstract.

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Artwork: Erica Tandori

Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling

Science 04 Jun 2021:
Vol. 372, Issue 6546, eabe9124
DOI: 10.1126/science.abe9124

Abstract.

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Artwork: Erica Tandori

Holding-the-Keys-to-Rheumatoid-Arthritis

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR

Science Immunology 16 Apr 2021:
Vol. 6, Issue 58, eabe0896
DOI: 10.1126/sciimmunol.abe0896

Summary. Abstract. TOC. Full text.

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Artwork: Erica Tandori

Obituary: Katharina Gaus 1972–2021

Nat Immunol (2021).

https://doi.org/10.1038/s41590-021-00915-30

Full text.

Image courtesy of ARC Centre of Excellence in Advanced Molecular Imaging

The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage

Science 2021, 371(6536),1383-1388
DOI: 10.1126/science.abe7070

Abstract. Full text. Reprint.

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Artwork: Erica Tandori

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

Nat Commun 12,2173 (2021).

https://doi.org/10.1038/s41467-021-22359-x

Abstract. Full text.

The Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

iScience. 2020, 23(7):101258

Open access article

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Artwork: Erica Tandori

The molecular basis underpinning the potency and specificity of MAIT cell antigens

Nat Immunol. 2020;10.1038/s41590-020-0616-6.

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Artwork: Erica Tandori

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

Sci Immunol. 2020 Jan 3;5(43). pii: eaax5430.

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Artwork: Erica Tandori

A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

Nature Cancer (2020). DOI: 10.1038/s43018-020-00111-6

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Artwork: Erica Tandori

Molecular-mimicry-in-Celiac-Disease,-by-Erica-Tandori-SMALL_edit

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.

Nat Struct Mol Biol. 2020 Jan;27(1):49-61

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Artwork: Erica Tandori

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

Sci Immunol. 2020;5(49):eabc9492.

Summary. Abstract. Full text.

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Artwork: Erica Tandori

jerome-paper-LETTERS-MERGED-WITH-CIRCLE-LATSEST-VERSION-TRANSPARENT-CIRCLE_400px

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Science. 2019;366(6472):1522-1527.

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Artwork: Erica Tandori

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

^{Nature. 2017 May 11;545(7653):243-247.}

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Artwork: Vanette Tran

CD4⁺ T cell-mediated HLA class II cross-restriction in HIV controllers.

Sci Immunol. 2018 Jun 8;3(24).

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Artwork: Vanette Tran

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

^{Cell. 2017;169(1):58-71.e14.}

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Artwork: Vanette Tran

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

^{Nat Immunol. 2017 Apr;18(4):402-411.}

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Artwork: Vanette Tran

Recent Publications

T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8.

Tran MT, Faridi P, Lim JJ, Ting YT, Onwukwe G, Bhattacharjee P, Jones CM, Tresoldi E, Cameron FJ, La Gruta NL, Purcell AW, Mannering SI, Rossjohn J, Reid HH.Nat Commun. 2021 Aug 25;12(1):5110. doi: 10.1038/s41467-021-25404-x.PMID: 34433824
Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d.

Almeida CF, Smith DGM, Cheng TY, Harpur CM, Batleska E, Nguyen-Robertson CV, Nguyen T, Thelemann T, Reddiex SJJ, Li S, Eckle SBG, Van Rhijn I, Rossjohn J, Uldrich AP, Moody DB, Williams SJ, Pellicci DG, Godfrey DI.Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2104420118. doi: 10.1073/pnas.2104420118.PMID: 34417291
A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation.

Frick R, Høydahl LS, Petersen J, du Pré MF, Kumari S, Berntsen G, Dewan AE, Jeliazkov JR, Gunnarsen KS, Frigstad T, Vik ES, Llerena C, Lundin KEA, Yaqub S, Jahnsen J, Gray JJ, Rossjohn J, Sollid LM, Sandlie I, Løset GÅ.Sci Immunol. 2021 Aug 20;6(62):eabg4925. doi: 10.1126/sciimmunol.abg4925.PMID: 34417258
Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein.

Chaurasia P, Nguyen THO, Rowntree LC, Juno JA, Wheatley AK, Kent SJ, Kedzierska K, Rossjohn J, Petersen J.J Biol Chem. 2021 Aug 9:101065. doi: 10.1016/j.jbc.2021.101065. Online ahead of print.PMID: 34384783
Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9.

Littler DR, Mohanty B, Lowery SA, Colson RN, Gully BS, Perlman S, Scanlon MJ, Rossjohn J.J Biol Chem. 2021 Jul 28;297(3):101018. doi: 10.1016/j.jbc.2021.101018. Online ahead of print.PMID: 34331944
A class of γδ T cell receptors recognize the underside of the antigen-presenting m Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.

Zhao Z, Wang H, Shi M, Zhu T, Pediongco T, Lim XY, Meehan BS, Nelson AG, Fairlie DP, Mak JYW, Eckle SBG, de Lima Moreira M, Tumpach C, Bramhall M, Williams CG, Lee HJ, Haque A, Evrard M, Rossjohn J, McCluskey J, Corbett AJ, Chen Z.Nat Commun. 2021 Jul 16;12(1):4355. doi: 10.1038/s41467-021-24570-2.PMID: 34272362
Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling.

Zareie P, Szeto C, Farenc C, Gunasinghe SD, Kolawole EM, Nguyen A, Blyth C, Sng XYX, Li J, Jones CM, Fulcher AJ, Jacobs JR, Wei Q, Wojciech L, Petersen J, Gascoigne NRJ, Evavold BD, Gaus K, Gras S, Rossjohn J, La Gruta NL.Science. 2021 Jun 4;372(6546):eabe9124. doi: 10.1126/science.abe9124.PMID: 34083463

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Full listing of publications

Rossjohn Laboratory

Publication Highlights

Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein

Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 non-structural protein 9

CD1a selectively captures endogenous cellular lipids that broadly block T cell response

Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR

Obituary: Katharina Gaus 1972–2021

The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

The Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

The molecular basis underpinning the potency and specificity of MAIT cell antigens

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

CD4⁺ T cell-mediated HLA class II cross-restriction in HIV controllers.

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Recent Publications

Click for full listing of publications

Full listing of publications

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